Epigenetics studies the heritable changes in phenotype that are independent of alterations in the DNA sequence itself. This course will examine the major epigenetic mechanisms. Particular attention will be paid to how the milestone discoveries in epigenetics were made. The course will also discuss the role of epigenetics in biological phenomena such as cellular reprogramming, X-inactivation, imprinting and the onset of human diseases.

CILO-1: Understand the major epigenetic mechanisms adopted by eukaryotic organisms to regulate gene expression. CILO-2: Become familiar with the current models of the inheritance of epigenetic changes. CILO-3: Understand the involvement of epigenetics in the development of human diseases. CILO-4: Become familiar with the basic methods of epigenetic research and develop critical thinking.